Using beta-lactam antibiotics in patients with a history of beta-lactam allergy: current concepts
نویسندگان
چکیده
منابع مشابه
The Survey of Genes Encoding Beta-Lactamases, in Escherichia Coli Resistant to Beta-Lactam and Non-Beta-Lactam Antibiotics
Objective(s) Resistance to the new generation of cephalosporins which is mediated by Extended-Spectrum beta-lactamases (ESBLs) has been found among Escherichia coli isolates throughout the world. These resistance genes and their producers, the micro-organisms carrying beta-lactamases, are responsible for serious clinical and therapeutic problems among inpatients and it is necessary to pay more...
متن کاملBeta-Lactam Antibiotics and Vancomycin Beta-lactam antibiotics
Anti-bacterial drugs have “selective toxicity”, that is they interact with a target present on the bacterial cell, the prokaryote, that is not present in the mammalian host, the eukaryote. For the ß-lactam drugs, this target is the cell wall. Mammalian cells lack cell walls, which for the bacteria are a critically important barrier protecting the organism from not only the vagaries of osmotic s...
متن کاملChemistry of Beta Lactam Antibiotics
Humans have been plagued with the threat of bacterial infection since before the dawn of recorded history, and have thus always had a keen interest in finding a suitable treatment for these maladies. In the early part of the 19th century, colonial Americans were fearful of death by bacterial infections that are now considered routine, and usually inquired about one another's health in their let...
متن کاملDesensitization in patients with beta-lactam drug allergy.
BACKGROUND Patients with a history of beta-lactam antibiotic allergy are often admitted to the hospital with severe or life-threatening infections requiring beta-lactam antibiotics. Strict avoidance of beta lactams to such patients may prevent them from getting adequate coverage and can lead to an increase in the use of alternative antibiotics, which can predispose to antibiotic resistance. Pas...
متن کاملGenetic associations in beta-lactam allergy
Immediate reactions to beta-lactams (BLs) are the most common allergic reactions against drugs and can be lifethreatening. The genetic risk factors influencing these reactions are poorly known, except those which were previously identified as predictors of atopy and inflammation. Two polymorphisms of nucleotide-binding oligomerization domain 2 (NOD2), a gene associated with chronic inflammatory...
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ژورنال
عنوان ژورنال: Polish Archives of Internal Medicine
سال: 2017
ISSN: 1897-9483
DOI: 10.20452/pamw.4066